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Metixene hydrochloride hydrate

Metixene hydrochloride hydrate
Metixene hydrochloride hydrate has potential anticholinergic activity and inhibits the binding of quinine ring benzoate (QNB) to muscarine receptors, with IC50 and Ki values of 55 nM and 15 nM, respectively. Metixene hydrochloride hydrate can be used to prevent and treat Parkinson's disease.
Catalog No. TQ0304Cas No. 7081-40-5
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Purity:99.88%
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Metixene hydrochloride hydrate

Catalog No. TQ0304Cas No. 7081-40-5

Metixene hydrochloride hydrate has potential anticholinergic activity and inhibits the binding of quinine ring benzoate (QNB) to muscarine receptors, with IC50 and Ki values of 55 nM and 15 nM, respectively. Metixene hydrochloride hydrate can be used to prevent and treat Parkinson's disease.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
5 mg$35In Stock
10 mg$55In Stock
25 mg$113In Stock
50 mg$178In Stock
100 mg$289In Stock
1 mL x 10 mM (in DMSO)$61In Stock
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Product Introduction

Bioactivity
Description
Metixene hydrochloride hydrate has potential anticholinergic activity and inhibits the binding of quinine ring benzoate (QNB) to muscarine receptors, with IC50 and Ki values of 55 nM and 15 nM, respectively. Metixene hydrochloride hydrate can be used to prevent and treat Parkinson's disease.
Targets&IC50
mAChR:55 nM, mAChR:15 nM (Ki)
In vitro
Metixene hydrochloride hydrate, with IC50 and Ki values of 55 nM and 15 nM, respectively, has the potential to inhibit the binding of QNB with the muscarinic receptor [1].
Chemical Properties
Molecular Weight363.95
FormulaC20H26ClNOS
Cas No.7081-40-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 5 mg/mL (13.74c), Sonication is recommended.
DMSO: 70 mg/mL (192.34 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7476 mL13.7382 mL27.4763 mL137.3815 mL
5 mM0.5495 mL2.7476 mL5.4953 mL27.4763 mL
10 mM0.2748 mL1.3738 mL2.7476 mL13.7382 mL
20 mM0.1374 mL0.6869 mL1.3738 mL6.8691 mL
50 mM0.0550 mL0.2748 mL0.5495 mL2.7476 mL
100 mM0.0275 mL0.1374 mL0.2748 mL1.3738 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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